A update on the hedge apple post...
FYI - I am happy to share hedge apples with anyone who has an interest and no access. All I ask is that you pay postage. It will be the end of August before their ready. Just let me know.
Read the original post here.
One reader commented with some excellent information and the research to back it up!
Thanks for all the good info, Brian! Scholarly articles promote critical thinking! Below are conclusions and URL's to some of the articles Mr. Barnabas provided, as it relates to Tetrahydroxystilbene glucoside or TSG (found in hedge apples):
3 - "Tetrahydroxystilbene glucoside not only prevents, i.e. at an early stage, the learning-memory deficit in AD-like model, but also can reverse the learning-memory deficit in the late stage of AD-like model. Thus, TSG could be considered among the future therapeutic drugs indicated for the treatment of AD."
https://www.ncbi.nlm.nih.gov/pubmed/16901557
4 - "TSG, which shows effects and mechanism in part like atorcastatin, is a major constituent with blood-lipid regulating effect of P. multiflorum and can be explored as a potent medication for hyperlipidemia. Effects on LDL-C and AI, as well as on gene expression of TSG were first reported."
https://www.ncbi.nlm.nih.gov/pubmed/17455469
5 - "In summary, the data showed that THSG possessed an anti-inflammatory effect, which was perhaps related to the inhibition of COX-2 enzyme activity and expression in RAW264.7 macrophage cells."
https://www.ncbi.nlm.nih.gov/pubmed/17613621
6 - "In conclusion, THSG possesses the antagonistic effects on oxidation of lipoprotein, proliferation and decrease of NO content of CASMCs, which partially explain the mechanism of anti-atherosclerosis of Polygonum multiflorum Thunb."
https://www.ncbi.nlm.nih.gov/pubmed/17701557
7 - "In conclusion, THSG exerts protective effects on experimental colitis through alleviating oxygen and nitrogen free radicals level and down-regulating iNOS expression."
https://www.ncbi.nlm.nih.gov/pubmed/17963744
8 - "In conclusion, hippocampal synapses count and synaptophysin expression decreased in aged rats, which may be one of the mechanisms involved in learning-memory deficit. TSG reversed the above changes in aged rats, suggesting that TSG may be beneficial for the treatment of Alzheimer disease or cognitive impairment in old people."
https://www.ncbi.nlm.nih.gov/pubmed/17935895
9 - The results suggest that the ability of THSG to trap reactive dicarbonyl species makes it a potential natural inhibitor of AGEs (advanced glycation end products. Many studies have shown that AGEs play a major pathogenic role in diabetes and its complications.
https://www.ncbi.nlm.nih.gov/pubmed/20104848
10 - "These findings indicate that the protective mechanisms of TSG on diabetic nephropathy are involved in the alleviation of oxidative stress injury and overexpression of COX-2 and TGF-β1, partially via activation of SIRT1."
https://www.ncbi.nlm.nih.gov/pubmed/20854812
11 - "Our data demonstrate that TSG promotes LTP induction and this effect may contribute to the enhancement of learning and memory seen in animal models."
https://www.ncbi.nlm.nih.gov/pubmed/20951128
I'm not a doctor, so I don't understand all of this science lingo - but it looks to me like the hedge apple may have more health benefits that I ever suspected. Medicine - straight from the source - Nature!!
Thanks again for all the good info Mr. Barnabas!
